Moonlighting – the performance of more than one function by a single protein – is becoming recognized as a common phenomenon with important implications for systems biology and human health. The different functions of a moonlighting protein may use different regions of the protein structure, or alternative structures that occur due to post-translational modifications and/or differences in binding partners. Often the different functions of moonlighting proteins are used at different times or in different places. The existence of moonlighting functions complicates (...) efforts to under- stand metabolic and regulatory networks, as well as physiological and pathological processes in organisms. Because moonlighting functions can play important roles in disease processes, an improved understanding of moonlighting proteins will provide new opportunities for pharmacological manipulations that specifically target a function involved in pathology while sparing physiologically important functions. (shrink)

Complexity is pleased to announce the installment of Prof Hiroki Sayama as its new Chief Editor. In this Editorial, Prof Sayama describes his feelings about his recent appointment, discusses some of the journal’s journey and relevance to current issues, and shares his vision and aspirations for its future.

The current U.S. health care system, with both rising costs and demands, is unsustainable. The combination of a sense of individual entitlement to health care and limited acceptance of individual responsibility with respect to personal health has contributed to a system which overspends and underperforms. This sense of entitlement has its roots in a perceived right to health care. Beginning with the so-called moral right to health care, the issue of who provides health care has evolved as individual rights have (...) trumped societal rights. The concept of government providing some level of health care ranges from limited government intervention, a ‘negative right to health care’, to various forms of a ‘positive right to health care’. The latter ranges from a decent minimum level of care to the best possible health care with access for all. We clarify the concept of legal rights as an entitlement to health care and present distributive and social justice counter arguments to present health care as a privilege that can be provided/earned/altered/revoked by governments. We propose that unlike a ‘right’, which is unconditional, a ‘privilege’ has limitations. Going forward, expectations about what will be made available should be lowered while taking personal responsibility for one’s health must for elevated. To have access to health care in the future will mean some loss of personal rights and an increase in personal responsibility for gaining or maintaining one’s health. (shrink)

Erratum to: Health Care Anal DOI 10.1007/s10728-013-0244-5In the original version of this paper, unfortunately, there happened to be a mistake in the paragraph “Several studies have compared health…better results or lower costs [7].” under the section “Health Care is NOT a Right?”The incorrect sentence is: For example, hip and knee replacements are not performed on Canadian and UK citizens after 77 .The correct sentence is: For example, hip and knee replacements in Canada and the UK are prioritized by age such (...) that older citizens are on a long waiting list. (shrink)

Locke’s theory of personal identity was philosophically groundbreaking for its attempt to establish a non-substantial identity condition. Locke states, “For the same consciousness being preserv’d, whether in the same or different Substances, the personal Identity is preserv’d” (II.xxvii.13). Many have interpreted Locke to think that consciousness identifies a self both synchronically and diachronically by attributing thoughts and actions to a self. Thus, many have attributed to Locke either a memory theory or an appropriation theory of personal identity. But the former (...) stumble on circularity and the latter is insufficient for Locke’s moral theory insofar as he is committed to a theory of divine rectification. The common problem is that Locke’s theory seems to demand an objective, or metaphysical, fact of a continuing consciousness that does not appeal to a traditional notion of substance for the continuity. I’m suggesting something new. In II.xxvii of the Essay, we see an ambiguity in Locke’s use of the term ‘consciousness’. Locke seems to see consciousness as both a mental state by means of which we are aware of ourselves as perceiving and as the ongoing self we are aware of in these conscious states. First, I make the textual argument why we should read Locke as having a conception of a metaphysical fact of a continuing consciousness that does not appeal to thinking or bodily substance to establish its continuity. I then argue that the metaphysical fact of an enduring consciousness is revealed to us as a phenomenological fact of experience. Due to the nature of certain kinds of perceptual situations we have an experience of ourselves as temporally extended. Although the text bears out that Locke seemed to think there is a fact of an ongoing consciousness, I argue that it is consistent with his reluctance elsewhere that he makes no further epistemological or ontological claims about it. Finally, I provide an account of Locke’s understanding of memory and its relation to consciousness that supports the claim that consciousness is something ontologically distinct from either thinking or bodily substance. (shrink)

I argue that Kant’s theory of art meets the challenge of strong non-perceptual art, an idea I extrapolate from James Shelley’s account of non-perceptual art. I endorse the spirit of Shelley’s account, but argue that his examples fail to support his case because he does not distinguish between strong and weak non-perceptual art. The former has no perceptible properties relevant to its appreciation as art; the latter is not exhausted by appreciation of those perceptible properties it does have. (...) I show this by comparing Marcel Duchamp’s Fountain and Robert Barry’s All the things I know. For Kant, appreciating art aesthetically as art requires: (1) awareness that it is art and (2) responsiveness to the ideas presented. Taken together, this allows Kant to accommodate strong non-perceptual art. I consider three challenges to this view: (a) Kant is committed to a representational theory of art; (b) Kant is committed to a restrictive formalism about aesthetic judgements of art; (c) Kant’s understanding of aesthetic pleasure commits him to a perceptual theory of art. I reply that: (i) this is grounded in empirical generalizations external to Kant’s theory; (ii) Kant’s strong formalist views are at odds with his account of ‘subjective purposiveness’, and the latter has priority; (iii) Kant is offering a general theory of art, which must accommodate both literature and strong non-perceptual art. (shrink)

"Alterity and Criticism: Retracing Time in Modern Literature" argues that the role of time in canonical literature underlies the experience of alterity and requires a new hermeneutic to clarify how the self emerges in literary texts. Romantic poetry from Goethe to Shelley and the modern prose tradition from Flaubert to Butor constitute different traditions but also indicate, on a textual basis, how alterity is crucial to reading, thus encouraging us to interpret literary texts in terms of the related concerns (...) of self, other and time. This volume engages in discussions of cultural semiotics and late phenomenology, and provides insights into how modern literature provides one way of assessing the possibility of World Literature for our own time. It will be of interest to students and scholars of both literature and philosophy. (shrink)

From US Supreme Court Justice Louis Brandeis’s 1933 judgement in Louis K Liggett Co v Lee to Matt Wuerker’s satirical cartoon “Corpenstein”, the use of Frankenstein’s monster as a metaphor for the modern corporation has been a common practice. This paper seeks to unpack and extend explicitly this metaphorical register via a recent filmic and graphic interpretation of Mary Shelley’s Frankenstein myth. Whilst Frankenstein has been read as an allegorical critique of rights—Victor Frankenstein’s creation of a monstrous body, reflecting (...) the figurative construction of a body by rights discourse—the metaphoric notion of reanimating a ‘soulless corpse’ resonates with Edward’s Thurlow’s description of the corporation as having ‘no soul to damn’. By exploring the figurative and optical representations of this process of reanimating the body in Scott Beattie’s film I, Frankenstein and Kevin Grevioux’s companion graphic novel I, Frankenstein: Genesis, I would like to extend this metaphoric register, by examining the theological origin and nature of the corporate form. This theology is explicitly referenced in the film and graphic novel via the battle between Gargoyles and Demons, which dominates the plot and backstory. The role of Frankenstein’s monster—now called Adam—however, is about enabling the reanimation of thousands of corpses without souls for possession by the demon hoard headed by Prince Naberius, who in his alternative persona Charles Wessex, controls the Wessex Institute and Wessex Industries. This ‘corporate baron’ himself has devoted his ‘life’ to enabling the rediscovery of Frankenstein’s ability to reanimate the dead for the purposes of gaining immortality. This mythic framing, however, renders explicitly visible the nature and purpose of the corporate form itself—of capturing and reanimating life in a form of immortality via the mechanisms of perpetual succession. This visual rendering, of a metaphoric framing goes to show the way in which the optical nature of the dominant forms of popular culture—film, television, comic books—provide a means for seeing law’s metaphorical images and for thus unpacking, interrogating and rendering them anew. It argues for a shift from the image of the corporation as a monstrous body to one which involves relations of reciprocity, gratuitousness and gift. (shrink)

Introduction Ce que nous proposons ici est un essai général, une tentative avec tout ce qu’elle comporte d’imparfait et d’incomplet, de rendre compte à travers une étape de son développement, du regard que porte la littéra­ture sur elle-même. Ce miroir littéraire nous semble en effet très bien explicité par la littérature romantique, qui choisit pour thème le regard sur soi et joue avec le lecteur sur la mise en abîme de ce regard. L’importance de ce miroir romantique repose sur l’idée (...) que sa... (shrink)

A multiple analogy is a structured comparison in which several sources are likened to a target. In "Multiple analogies in science and philosophy," Shelley provides a thorough account of the cognitive representations and processes that participate in multiple analogy formation. Through analysis of real examples taken from the fields of evolutionary biology, archaeology, and Plato's "Republic," Shelley argues that multiple analogies are not simply concatenated single analogies but are instead the general form of analogical inference, of which single (...) analogies are a special case. The result is a truly general cognitive model of analogical inference.Shelley also shows how a cognitive account of multiple analogies addresses important philosophical issues such as the confidence that one may have in an analogical explanation, and the role of analogy in science and philosophy.This book lucidly demonstrates that important questions regarding analogical inference cannot be answered adequately by consideration of single analogies alone. (shrink)

In Byron, Shelley, and Goethe’s Faust, author Ben Hewitt has provided us with a carefully done and convincing study. Given this, it would have been interesting to see Hewitt’s effort to integrate Mary Shelley’s work into his narrative. Apart from any similarities between Faust and Frankenstein, it bears remembering that Goethe himself remained unconvinced by efforts to clearly demarcate works as “tragic” or “epic”; a fact that becomes especially clear in the number of works he’d devoted to rewriting (...) the story of Prometheus. One cannot help but wish that Hewitt had considered the connection between these works and Shelley’s own “Modern Prometheus” in juxtaposition to his reading of P.B. Shelley’s Prometheus Unbound, for this would have made for an especially good ending to Hewitt’s story. Wayne Deakin’s consideration of Hegel and the English Romantic Tradition does indeed close with a brief consideration of Mary Shelley’s Prometheus, but this comes only at the end of a much longer set of considerations. In this book Deakin adopts a similar strategy as that of Hewitt, namely, foregoing any historical recovery of Hegel’s direct influence on the English Romantics—in Deakin’s case, Coleridge, Wordsworth, and P.B. Shelley—to focus instead on a reading of key poetic works in concert with their Hegelian framework. This reading essentially flows from Deakin’s effort to rethink Hegel’s relatively early notion of self-consciousness through his late lectures on aesthetics. For Deakin, this leads to “aesthetic recognition”; a situating of the self in relation to the world that remains in tension so far as the subject’s drive for autonomy will automatically be humbled by its reception of and to alterity—be that other “Nature” or other subject. (shrink)

Serena Olsaretti brings together new essays by leading moral and political philosophers on the nature of desert and justice, their relations with each other and with other values.

This article is a feminist intervention into the ways that disability is researched and represented in philosophy at present. Nevertheless, some of the claims that I make over the course of the article are also pertinent to the marginalization in philosophy of other areas of inquiry, including philosophy of race, feminist philosophy more broadly, indigenous philosophies, and LGBTQI philosophy. Although the discipline of philosophy largely continues to operate under the guise of neutrality, rationality, and objectivity, the institutionalized structure of the (...) discipline implicitly and explicitly promotes certain ontologies, epistemologies, and methodologies as bona fide philosophy, while casting the ontologies, epistemologies, and methodologies of marginalized philosophies as mere simulacra of allegedly fundamental ways of knowing and doing philosophy and thus rendering these marginalized philosophies more or less expendable. This article is designed to show that legitimized philosophical discourses are vital mechanisms in the problematization of disability. (shrink)

The Picturesque (a set of theories, ideas, and conventions which grew up around the question of how we look at landscape) offers a valuable focus for new investigations into the literary, artistic, social, and cultural history of the late eighteenth and nineteenth centuries. This volume of essays by scholars from various disciplines in Britain and America incorporates a range of historically and theoretically challenging approaches to the topic. It covers the writers most closely identified with the exposition of the Picturesque (...) as a theory, and also traces the influence and implications of its aesthetic in a variety of fields in the Romantic period, including literary and pictorial works, estate management, and women's fashion. Several essays deal more specifically with radical critiques and appropriations of the Picturesque in the nineteenth century, while in others, its influence is traced beyond traditionally accepted geographical or historical bounds. (shrink)

The basic principles of scientific research from the great French physiologist whose contributions in the 19th century included the discovery of vasomotor nerves; nature of curare and other poisons in human body; more.

Critical diversity studies (CDS) can be found within “traditional,” or “established,” university disciplines, such as philosophy, as well as in relatively newer departments of the university, such as African studies departments, women’s and gender studies departments, and disability studies departments. In this article, therefore, I explain why philosophy of disability, an emerging subfield in the discipline of philosophy, should be recognized as an emerging area of CDS also. My discussion in the article situates philosophy of disability in CDS by both (...) distinguishing this new subfield’s claims about disability from the arguments about disability that mainstream philosophers make and identifying the assumptions about social construction and antiessentialism that philosophy of disability shares with other areas of CDS. The discussion is designed to show that a (feminist) philosophy of disability that draws upon the work of Michel Foucault will transform how philosophers understand the situation of disabled people. By drawing upon Foucault, that is, I offer philosophers of disability and other practitioners of CDS a new understanding of disability as an apparatus of power relations. -/- . (shrink)

According to the perspective developed in this article, widely shared, hegemonic cultural beliefs about gender and their impact in what the authors call “social relational” contexts are among the core components that maintain and change the gender system. When gender is salient in these ubiquitous contexts, cultural beliefs about gender function as part of the rules of the game, biasing the behaviors, performances, and evaluations of otherwise similar men and women in systematic ways that the authors specify. While the biasing (...) impact of gender beliefs may be small in any one instance, the consequences cumulate over individuals’ lives and result in substantially different outcomes for men and women. After describing this perspective, the authors show how it sheds newlight on some defining features of the gender system and illustrate its implications for research into specific questions about gender inequality. (shrink)

Introduction Dans les premiers vers de son Roland Furieux, L'Arioste écrit : « Je dirai [...] comment, par amour, il devint furieux et fou, d’homme qui auparavant avait été tenu pour si sage. Je le dirai, si, par celle qui en a fait quasi autant de moi en m’enlevant par moments le peu d’esprit que j’ai, il m’en est pourtant assez laissé pour qu’il me suffise à achever tout ce que j’ai promis ». Ainsi, craint-il, par amour, de perdre la (...) raison avant d'avoir terminé son œuvre mais surtout de se... (shrink)

"Then to this earthen Bowl did I adjourn My Lip the secret Well of Life to learn: And Lip to Lip it murmur'd-"While you live Drink!-for once dead you never shall return." " [http://philpapers.org/profile/112741] .

This paper examines the possibility of parenting as a queer practice. Examining definitions of “queer” as resistant to presumptions and practices of reprosexuality and repro-narrativity (Michael Warner), bourgeouis norms of domestic space and family time (Judith Halberstam), and policies of reproductive futurism (Lee Edelman), I argue that queer parenting is possible. Indeed, parenting that resists practices of normalization are, in part, realized by certain types of postmodern families. However, fully actualizing the possibility of parenting queerly—and thus teaching our children the (...) values of non-normativity--requires engaging political struggles for distributive justice. These are, thus, the struggles that should be at the center of queer politics, rather than the current struggles for gay marriage and homoparental rights. (shrink)

We propose an account of dynamic predicates which draws on the notion of force, eliminating reference to events in the linguistic semantics. We treat dynamic predicates as predicates of forces, represented as functions from an initial situation to a final situation that occurs ceteris paribus, that is, if nothing external intervenes. The possibility that opposing forces might intervene to prevent the transition to a given final situation leads us to a novel analysis of non-culminating accomplishment predicates in a variety of (...) languages, including the English progressive. We then apply the force-theoretic framework to the composition of basic Vendlerian eventuality types within a lexical-decomposition syntax. The difference between predicates of forces and predicates of situations is argued to underlie the dynamic/stative contrast, and also to allow for a formal treatment of the difference between be and stay. Consequences for the relationship between language and cognition are discussed. (shrink)

In its simplest form, hedonism about aesthetic value, the standard account of aesthetic normativity, holds that an object’s aesthetic value is the value it possesses in virtue of its capacity to provide aesthetic pleasure. I argue that hedonism cannot be true because it cannot reconcile itself with our concern to make true aesthetic judgments. Then I argue for an alternative account of aesthetic normativity that is not only consistent with that concern but the very expression of it. The argument for (...) the alternative account largely consists of arguments against two theses associated with Kant: subjectivism, which holds that the ascription of aesthetic value to an object depends on the sentiments of the subject making the ascription and not on the subject’s recognition of a property residing in the object, and disinterestedness, which holds that the ascription of beauty to an object neither depends on nor results in the subject’s having a motive to act in regard to the object. -/- . (shrink)

Critics of so-called ideal theory argue that prevailing liberal egalitarian principles were constructed under idealized assumptions and thus are ill suited to real-world circumstances where such assumptions do not apply. Specifically, they raise three related objections: ideal theory cannot help us understand current injustices in the actual, nonideal world, ideal principles are not sufficiently action-guiding, and ideal theory tends to reflect and perpetuate unjust group privilege. This chapter explores recent philosophical work on immigration in light of these criticisms. I argue (...) that prominent arguments on both sides of the open borders debate are subject to the standard criticisms of ideal theory and thus that a nonideal approach to migration justice is urgently needed. I suggest several methodological desiderata for such an approach. (shrink)

In two studies, we used the Ethics Position Questionnaire (EPQ) to investigate the relationship between individual differences in moral philosophy, involvement in the animal rights movement, and attitudes toward the treatment of animals. In the first, 600 animal rights activists attending a national demonstration and 266 nonactivist college students were given the EPQ. Analysis of the returns from 157 activists and 198 students indicated that the activists were more likely than the students to hold an "absolutist" moral orientation (high idealism, (...) low relativism). In the second study, 169 students were given the EPQ with a scale designed to measure attitudes toward the treatment of animals. Multiple regression showed that gender and the EPQ dimension of idealism were related to attitudes toward animal use. (shrink)

An examination of the debates over the so-called 'false' memory syndrome. In this paper, I concur that memory is malleable, but interrogate notions of truth and falsity underlying standards used to evaluate the accuracy of memories of abuse. Such standards divert us, I suggest, from recognizing the truth behind widespread recollections of abuse at the hands of patriarchy.

This paper seeks to differentiate negative properties from positive properties, with the aim of providing the groundwork for further discussion about whether there is anything that corresponds to either of these notions. We differentiate negative and positive properties in terms of their functional role, before drawing out the metaphysical implications of proceeding in this fashion. We show that if the difference between negative and positive properties tabled here is correct, then negative properties are metaphysically contentious entities, entities that many philosophers (...) will be unwilling to countenance. (shrink)

The systems of belief by the ancient Hebrews of the Old Testament and the current Kenyan tribe of Torobo demonstrate both ancient and modern tribal world view in which the religious is interconnected to all aspects of personal existence within each individual. The most important word in the vocabulary of biblical Hebrew and Torobo anthropology is ‘heart’. Lēḇ (Hebrew ‘heart’) and oltau (Torobo ‘heart’) are divinely ordained conceptual catalysts representing the composite nature of humanity. This paper will explore the concept (...) of heart as the principal, unifying object of attention employed throughout biblical Hebrew and Torobo world view that integrates psychical elements of Self as a cohesive medium for supernatural interaction and moral deportment. (shrink)

This article engages critically with issues surrounding the theorization of the self and body relation, where the body is interpreted as material increasingly open to human intervention and choice. It is argued that this theorization rests upon a mind/body split that limits an understanding of embodied identity. The significance for feminism of undermining representational practices that rely upon this dualism are outlined and criticized for reproducing the logic of representation they set out to destabilize. An alternative strategy is examined and (...) the argument is made that to understand embodied identity the question must not be what do bodies mean but what can they do. Here feminist approaches that rely upon a radically different ontological position in order to move beyond the mind/body split are utilized. These theoretical debates are made meaningful through the lens of self narratives produced by young women–a context which demands the development of strategies for theorizing lived bodies. (shrink)

The increased visibility of feminism in mainstream culture has recently been noted, with the presence of both online and offline campaigns embedding feminist claims in a variety of everyday spaces. By granting recognition to women’s experiences, these campaigns continue the feminist practice of generating critical knowledge on the basis of gendered experience. In the post-truth era, however, the norms governing claims-making are being significantly reconstructed, with significant consequences for critiques of gender inequality. It is argued here that these norms are (...) linked directly to a wider context of anti-feminism in which dismissing women’s claims is consistent with the goal that opponents of gender equality have of seeking and consolidating epistemic power in the face of what is perceived as systemic male disadvantage and victimhood. Returning to earlier debates within feminism, it is argued that the kinds of post-truth rhetoric used to dismiss women’s experience provide a challenge that feminism must confront. This rhetoric is often grounded in the authenticity of individual experience; however, experience cannot provide unmediated access to truth and, therefore, cannot provide the foundation for feminist claims. On the other hand, experience cannot merely offer one of many contested versions of ‘reality’. The excesses of both foundationalist and anti-foundationalist epistemology are countered with the argument that cognition is a human practice mediated by theoretical propositions which illuminate the question of what can be known. This is the role played by feminist theory in defending the role of experience. (shrink)

Witty, sexy and radiantly beautiful, the Shelley translationof Plato's great Dialogue on Love is by far the best in theEnglish language. It has been described as conveying "much of the vivid life, the grace of movement, and the luminous beauty of Plato" -- "the poetry of a philosopher rendered by the prose of a poet." Although a masterpiece in its own right, the Shelley translation was suppressed and then bowdlerized for well over a century. In 19th century Britain, (...) male love -- at the heart of the dialogue -- was unmentionable. The Banquet and Shelley's accompanying essay, "A Discourse on the Manners of the Antient Greeks," were not published in their entirety until 1931, and then in an edition of 100 copies intended "for private circulation only." The Pagan Press edition is complete, authentic and readable. For the first time this work has received the editing and typography it deserves. (shrink)

This research proposes and tests a new theoretical mechanism to account for a portion of the motherhood penalty in wages and related labor market outcomes. At least a portion of this penalty is attributable to discrimination based on the assumption that mothers are less competent and committed than other types of workers. But what happens when mothers definitively prove their competence and commitment? In this study, we examine whether mothers face discrimination in labor-market-type evaluations even when they provide indisputable evidence (...) that they are competent and committed to paid work. We test the hypothesis that evaluators discriminate against highly successful mothers by viewing them as less warm, less likable, and more interpersonally hostile than otherwise similar workers who are not mothers. The results support this “normative discrimination” hypothesis for female but not male evaluators. The findings have important implications for understanding the nature and persistence of discrimination toward mothers. (shrink)

Intimacies and domestic lives -- Reproduction.

The accumulation and advancement of gender scholarship over past decades has led us to the point where gender scholars today can leverage our deep understanding of the reproduction of gender inequality to develop and test models of change. In this lecture, I present one such model designed to reduce the negative effects of stereotypic biases on women’s workplace outcomes. After synthesizing the literature on stereotyping and bias and showing the limits of past change efforts, I develop a “small wins” model (...) of change. Key to this model is that researchers work with teams of managers to produce concrete, implementable actions that produce visible results. I argue that small wins motivate further action and are the building blocks to larger organizational transformation. Preliminary results from several case studies show that this approach can produce important changes in the short run, such as reducing gender biases in workplace evaluations, and that these small wins can inspire longer run change, such as increases in the rate of hiring women. (shrink)

This article aims to contribute to literature on the conceptualisation of ‘vulnerability’ and its use by neo-liberal welfare regimes to demean, stigmatize and responsibilize welfare recipients. Several conceptions of ‘vulnerability’ will be explored and utilised in the context of welfare reforms that purport to regulate social security recipients as highly risky ‘vulnerable’ subjects. However, as this article will make clear, ‘vulnerability’ is a somewhat slippery concept and one susceptible to abuse by powerful interests intent on increasing coercive surveillance, discipline and (...) disentitlement for those designated as ‘vulnerable’. Legislation enacted ostensibly to address the ‘vulnerability’ of welfare recipients can foster intensive regulation and it must be asked who benefits most from such arrangements and the rhetoric that supports them. (shrink)